BIO 5406
McGilliard
 

Reading Assignment:

     Hadley, pp. 4-5, 7, 22-36, 39-53, 57-64.
 

Objectives:

     After reviewing your lecture notes and reading assignment, you should be able to:

     1.  Distinguish between endocrine and exocrine glands.

          Lecture -- 1/09
          Text -- pg. 7
          Formation of Exocrine and Endocrine Glands

     2.  Describe the general histological features of an endocrine gland.

          Lecture -- 1/09
          Figures -- 11.1, 13.3, 15.2
          Pancreas -- Islets of Langerhans (clumps)
          Adrenal Cortex (cords)
          Thyroid Gland (follicles)

     3.  Identify four chemical classes of hormones and describe the biosynthesis, storage,
          secretion, and transport in blood for each class.

          Lecture -- 1/09, 1/11
          Text -- pp. 22-24, 27-32

          Figures -- 2.1, 2.2, 13.1, 13.5, 14.1, 14.3, 15.3

          Peptide Hormone Biosynthesis

          Proinsulin

     4.  Name four characteristics of hormone receptor binding.

          Lecture -- 1/11

          Text -- pp. 39-42

          Figure -- 3.1
 
     5.  Describe the receptor binding characteristics and post-receptor mechanisms of
          action of each class of hormones.

          Lecture -- 1/11, 1/14
          Text -- pp. 45-53, 57-64
          Figures -- 3.5, 3.6, 3.7, 3.11, 3.12, 3.15
          Structure of the Beta-adrenergic Receptor
          Signal Transduction in Cells
          Activation and Inactivation of the G Protein
          Cyclic AMP Second Messenger System
          Mechanism of Steroid Hormone Action
          Mechanism of Thyroid Hormone Action

     6.  Describe a significant contribution of the following scientists to the field
          of endocrinology.
          a.  Earl Sutherland and Theodore Rall.
          b.  Alfred Gilman and Martin Rodbell.

          Lecture -- 1/14
          Text -- pp. 4-5, 46-49
          1971 Nobel Press Release  --  Recommended reading!
          1994 Nobel Press Release