BIO 5406
McGilliard
 

Reading Assignment:

     Hadley, pp. 366-378, 380-384, 387-404.

     Carani, C., et al.  Effect of testosterone and estradiol in a man with aromatase deficiency.
          New England Journal of Medicine 337: 91-95, 1997.
 

Objectives:

     After reviewing your lecture notes and reading assignment, you should be able to:

     1.  Describe the roles of the sex chromosomes and hormones in the prenatal
          development of the gonads and sex accessory organs.

          Lecture -- 3/21

          Text -- pp. 366-370
          Figures -- 16.1, 16.2, 16.4, 16.5
          Sex differentiation in the male

          Sex differentiation in the female

          Differentiation of sex accessory organs
          Development of external genitalia

     2.  Contrast hermaphrodite and pseudohermaphrodite and describe two examples of

          pseudohermaphroditism.

          Lecture -- 3/21

          Text -- pp. 380-382
          Table -- 16.1

     3.  Describe the cell types and key enzymes involved in androgen biosynthesis.

          Lecture -- 3/23

          Text -- pp. 370-373, 388-389
          Figures -- 16.6, 17.1, 17.4
          Cross-section of testis (sketch)
          Seminiferous tubule and Leydig cells
          Leydig cells

     4.  Describe the feedback control of testosterone secretion in the male.

          Lecture -- 3/23

          Text -- pp. 389-391
          Figure -- 17.3
          Control of testosterone secretion

     5.  Describe the receptor mechanism involved in the action of testosterone.

          Lecture -- 3/23

          Text -- pp. 372, 392, 398-399
          Figures -- 16.7, 16.10, 17.6
          Formation of dihydrotestosterone
 

     6.  List the androgenic, anabolic, and behavioral actions of testosterone.

          Lecture -- 3/23, 3/25

          Text -- pp. 375-378, 392-397
          Table -- 17.1
          Carani paper

     7.  Describe the sites, sequence of events, and hormonal control of spermatogenesis.

          Lecture -- 3/28

          Text -- pp. 392-393
          Figure -- 17.1
          Spermatogenesis
          Sertoli cell and spermatogenesis
          Hormonal control of spermatogenesis
          Testis (low power)
          Seminiferous tubules (low power)
          Seminiferous tubule, showing sertoli cells (a), primary spermatocytes (b), spermatids (c),
               and spermatogonia (d)
          Sertoli cell, primary spermatocytes and spermatids (high power)
          Sertoli cells (high power)

     8.  Describe the uses and abuses of anabolic-androgenic steroids.

          Lecture -- 3/25

          Text -- pg. 397

     9.  List six adverse effects associated with administration of high doses of androgens.
 

          Lecture -- 3/28

          Text -- pg. 397

   10.  Describe the mechanisms of action and therapeutic uses of antiandrogens and
          5-alpha-reductase inhibitors.

          Lecture -- 3/25, 3/28

          Text -- pg. 400
          Figures -- 16.7, 17.7

   11.  Discuss methods of contraception available to the male and prospects for future
          male contraceptives.