BIO 5406
McGilliard
 

Reading Assignment:

     Hadley, pp. 293-310, 312.

     Roueche, B.  The case of the lean cuisine.  Medical Economics, Sept. 5, 1988, pp. 96-110.
 

Objectives:

     After reviewing your lecture notes and reading assignment, you should be able to:

     1.  Describe the location and anatomy of the mammalian thyroid gland.

          Lecture -- 2/04
          Figure -- 13.2
          Text -- pp. 293-294
          Human thyroid gland

     2.  Describe the thyroid follicle and the structural changes produced by thyrotropin

          (TSH).

          Lecture -- 2/04
          Text -- pp. 294-295
          Figure -- 13.3
          Section of thyroid (low power)

     3.  Identify thyroid follicular cells and parafollicular cells on a histologic section.

          Lecture -- 2/04
          Text -- pg. 294
          Figure -- 13.3
          Section of thyroid (medium power)
          Thyroid parafollicular cells

     4.  Describe, in detail, the biosynthesis of thyroxine (T₄) and triiodothyronine (T₃).

          Lecture -- 2/08
          Text -- pp. 295-298
          Figures -- 13.1, 13.4, 13.5, 13.8
          Production and storage of thyroid hormones

     5.  Explain the importance of iodine in thyroid function and the consequences of

          iodine deficiency.

          Lecture -- 2/08
          Text -- pp. 295-297, 306
          Endemic goiter
          Mechanism of endemic goiter

     6.  Describe the cellular mechanism of action of thyroxine.

          Lecture -- 2/08
          Text -- pp. 302-304
          Figure -- 13.10
          Mechanism of action of thyroid hormones

     7.  Describe the actions of thyroxine on:
          a.  Growth and development.
          b.  Metabolic rate and heat production.
          c.  Reproduction.
          d.  Molting and hair growth.

          Lecture -- 2/08
          Text -- pp. 300-302, 312
          Table -- 13.1

     8.  Draw a control system diagram and explain the feedback control of thyroxine

          secretion.

          Lecture -- 2/11
          Text -- pg. 299
          Figure -- 13.9
          Feedback control of thyroxine secretion
          Animation

     9.  Describe the types, causes, symptoms, and treatments of hypothyroidism and

          hyperthyroidism.

          Lecture -- 2/11
          Text -- pp. 304-310
          Figures -- 13.11, 13.12
          Tables -- 13.2, 13.3
          Section of thyroid (hyperthyroidism)
          Exophthalmos

   10.  Describe the contributions of the following scientists to our understanding of the

          thyroid gland:
          a.  Theodor Kocher.
          b.  George Murray.
          c.  Edward Kendall.

          Lecture -- 2/04
          Text -- pg. 293
          Handout:  Important Discoveries Related to the Thyroid Gland
          1909 Nobel Presentation Speech