Biological Sciences
Gary A. Bulla, Ph.D.
Links to Courses
Bio1001- Biological Principles and Issues
Bio1100-General Biology
Bio2001G-Human Physiology
Bio3101-Molec/Cell/ lab
Bio4751- Advanced Molecular and Cellular Biology 
Laboratory group
Research Interests
Research opportunities
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Tian L, Bulla GA. Demethylation And Hyperacetylation Fails To Activate Hepatic Gene Expression In Dedifferentiated Hepatoma Cells. (Submitted for publication) 

Reidy MR,  Ellis JA Schmitz EK, Kraus DM, Bulla GA. Protection from LPS-mediated apoptosis of dedifferentiated hepatoma cells is independent of  NF-?B activation. Bioscience Reports  27:235-46, 2007.

Bulla GA, Kraus,DM. Dissociation of the Hepatic Phenotype from HNF4 and HNF1a Expression Bioscience Reports,   24:595-608, 2005.

Schmitz EK, Kraus DM, Bulla GA. Tissue-specificity of apoptosis hepatoma-derived cell lines. Apoptosis, 9:369-375, 2004.

Kraus DM, Bulla GA. Defective NF-kB signaling in dedifferentiated hepatoma cells. Somat. Cell. Molec. Genet., 27:275-286, 2002.

Kladney, RD, Cui C, Bulla, GA, Fimmel CJ.Disease- and cell-specific expression of GP73, a novel Golgi protein: evidence for virus-dependent and -independent regulation in hepatocytes. Hepatology, 35:1431-1440, 2002.

 Bulla GA, Givens E, Brown S, Oladiran B, Kraus D. Protection of  dedifferentiated hepatoma variant cells from  LPS-induced apoptosis by restoration of hepatic gene expression. J. Cell Science, 114:1205-1212, 2001

Kladney R, Bulla GA, Guo, L, Mason AL, Tolleffson AE, Simon DJ, Koutoubi Z, Fimmel C. GP73, a novel Golgi-localized protein upregulated by viral infection. Gene 249:53-65, 2000.

Bulla GA.  Extinction of a1-antitrypsin gene expression in somatic cell hybrids is  independent of loss of HNF1a and HNF4  in somatic cell hybrids. Nucl. Acids Res. 27: 1190-1197, 1999.

Khalkhali-Ellis Z, Bulla GA, Schlesinger LS, Kirschmann DA Moore TL, Hendrix MJC. C1q containing immune complexes purified from sera of juvenile rheumatoid arthritis patients mediate IL-8 production by human synoviocytes: Role of C1Q  receptors. J. Immunol. 163:4612-4620, 1999.

Bellezzo JM, Leingang KA, Bulla GA, Britton RS, Bacon BR, Fox ES. Modulation of  lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants  J. Lab. Clin. Med. 131:36-44, 1998.

Bulla GA, Batanian J, Young H, Bradley N, Kazi N, Haddad, B.  Rescue of the HNF4-HNF1a pathway in hepatoma variant cells containing human chromosomal 12. Genomics 54:398-407, 1998.

Bulla GA. Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids.  Nucl. Acids. Res. 25:2501-2508, 1997.
Bulla GA. Selective loss of the hepatic phenotype due to the absence of a transcriptional activation pathway Somat. Cell  Molec.Genet. 23: 185-202,1997

Schafer AJ, Bulla GA, Fournier REK.  Tissue-specific extinguisher loci in the murine genome: A screening study based on a rat/mouse microcell hybrid panel. Somat.Cell Mol. Genet. 20: 195-213, 1994.

Bulla GA, Fournier REK. Genetic analyses of a transcriptional activation pathway using hepatoma cell variants. Mol. Cell. Biol. 14:7086-7094, 1994.

Bulla GA, DeSimon V, Cortese R, Fournier REK. Extinction of al-antitrypsin gene expression in somatic cell hybrids: Evidence for multiple controls. Genes and Development 6:316-327, 1992.

Bulla GA, Fournier REK. Direct selection of hepatoma cell variants deficient in a1-antitrypsin gene expression. Somat Cell Mol Genet. 18: 361-370, 1992.

Bulla GA, Siddiqui A. Negative regulation of the hepatitis B virus pre-S1 promoter by internal DNA sequences. Virology 170: 151-260, 1990.

Bulla GA, Siddiqui A. The hepatitis B virus enhancer modulates transcription of the HBsAg gene from an internal location. J. Virol. 63: 1437-1441, 1988.

Collins JK, Bulla GA, Reigel CA, Butcher AC.  A single dilution enzyme linked  immunosorbent assay for herpes virus type I. Vet. Micro. 10:133-147, 1985.